Journal article
RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas
S Deb, H Xu, J Tuynman, J George, Y Yan, J Li, RL Ward, N Mortensen, NJ Hawkins, MJ McKay, RG Ramsay, SB Fox
British Journal of Cancer | NATURE PUBLISHING GROUP | Published : 2014
DOI: 10.1038/bjc.2014.31
Abstract
Background: RAD21 is a component of the cohesion complex and is integral to chromosome segregation and error-free DNA repair. RAD21 is functionally important in tumour progression but its role in colorectal carcinoma (CRC) is unclear. We therefore assessed its clinicopathological and prognostic significance in CRC, as well as its effect on chemosensitivity. Methods: A retrospective observation study examined RAD21 expression in 652 CRCs using a tissue microarray approach. Correlation with clinicopathological factors including gender, tumour grade, mucinous subtype, TNM stage, disease-specific survival (DSS), BRAF and KRAS mutation status, tumour p53 immunostaining, tumour microsatellite inst..
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Funding Acknowledgements
This work is support by the National Health and Medical Research Council (NHMRC) project grant to RGR, HX and MJM. Tissue microarrays were provided by the Lowy Biorepository, University of NSW, Sydney, with support from the Translational Cancer Research Network, NSW. We thank the microscopy core for assistance with histology and image analysis.